In addition to correcting the serum sodium, the management of hyponatraemia must always include treatment of the underlying cause. Verbalis JG, Goldsmith SR, Greenberg A, Schrier RW, Sterns RH. The prevalence of hyponatraemia in widely different conditions and the fact that hyponatraemia is managed by clinicians with a broad variety of backgrounds have fostered diverse institution- and speciality-based approaches to diagnosis and treatment. We acknowledge the provision of funding from the Australian Government Department of Health to develop and maintain this website. Our information hub has important information for everyone. Treatment of hypervolemic hyponatremia in patients with cirrhosis is a challenge. This is the only situation in which the use of isotonic saline is appropriate treatment for hyponatraemia. Timely, independent, evidence-based information on new drugs and medical tests, and changes to the PBS and MBS. Treatment starts with the examination of the condition to determine if one has euvolemic, hypervolemic or hypovolemic condition; Excessively rapid restoration of serum sodium, and 'overcorrection' of serum sodium above the normal range, have been associated with cerebral demyelination which is irreversible and frequently fatal, and may not be evident for several days after treatment has been completed. Severe or symptomatic hyponatraemia should be treated as a medical emergency. exercise-associated hyponatraemia (due to excessive hypotonic fluid intake in the setting of increased antidiuretic hormone secretion). Are there any signs suggestive of malignancy as a cause of syndrome of inappropriate antidiuretic hormone secretion? Hyponatremia Algorithm. This causes a dilutional fall in serum sodium while at the same time raising the serum osmolality. 20 years of helping Australians make better decisions about medicines, medical tests and other health technologies. Semin Nephrol 2009;29:282-99. Read our privacy policy. A urine sodium under 20 mmol/L indicates hypovolaemic hyponatraemia where the sodium loss is of extra-renal origin as the kidneys are reabsorbing sodium. In its severe form it has a high morbidity and mortality. Patients with severe (serum sodium ≤120 mEq/L), symptomatic hyponatremia can develop life-threatening or fatal complications from cerebral edema if treatment is inadequate and permanent neurologic disability from osmotic demyelination if treatment is excessive. It is the most common form of hyponatraemia. Therapy of central pontine myelinolysis following liver transplantation: report of three cases. Isotonic saline is contraindicated as it can be associated with a further fall in serum sodium. High urinary sodium concentrations can also be seen in hyponatraemia associated with renal salt wasting and renal failure, and in patients on diuretic therapy.
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